BDBM19423 HDAC inhibitor, Compound 1::N-[2-amino-5-(thiophen-2-yl)phenyl]-4-acetamidobenzamide::N-[2-amino-5-(thiophen-2-yl)phenyl]-4-acetamidobenzamide (60)::SHI-1:2::benzamide-type inhibitor, 19

SMILES CC(=O)Nc1ccc(cc1)C(=O)Nc1cc(ccc1N)-c1cccs1

InChI Key InChIKey=ABZSPJVXTTUFAA-UHFFFAOYSA-N

Data  6 KI  53 IC50  2 Kd

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 19423   

TargetHistone deacetylase 5(Homo sapiens (Human))
Wayne State University

LigandPNGBDBM19423(HDAC inhibitor, Compound 1 | N-[2-amino-5-(thiophe...)
Affinity DataIC50: >1.00E+4nMpH: 8.0 T: 2°CAssay Description:Following transfection of HEK293 cells with pBJ5-HDAC1 wild type or mutant plasmids, [Weerasinghe et al., J. Med. Chem. 51:5542-5551; Wambua et al., ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 5(Homo sapiens (Human))
Wayne State University

LigandPNGBDBM19423(HDAC inhibitor, Compound 1 | N-[2-amino-5-(thiophe...)
Affinity DataIC50: >1.00E+4nMpH: 7.5Assay Description:Biochemical assays of HDAC activity were carried out by Nanosyn in a reaction volume of 10 ul in 384-well microplates. A standard enzymatic reaction ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 5(Homo sapiens (Human))
Wayne State University

LigandPNGBDBM19423(HDAC inhibitor, Compound 1 | N-[2-amino-5-(thiophe...)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of HDAC5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 5(Homo sapiens (Human))
Wayne State University

LigandPNGBDBM19423(HDAC inhibitor, Compound 1 | N-[2-amino-5-(thiophe...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of HDAC5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed